关键词: 犬, 嗅辨, 肺癌, 肿瘤筛查

Abstract: Objective To evaluate the sensitivity and specificity of sniffer dog on diagnosis of human lung cancer. Method Blood was collected from 25 patients with lung cancer and 127 volunteers in the control group. Serum was used to be identified by sniffer dog under a double-blind setting. Result The sensitivity and specificity of sniffer dog identification of human lung cancer from normal control were 100% ( 95% CI:86. 3% - 100. 0%) , 99. 2% ( 95% CI:95. 7% - 99. 9%) , respectively. The positive predictive value was 96. 2% ( 95% CI:78. 0% - 99. 4%) and the negative predictive value was 100%. The accuracy of sniffer dog on diagnosis of human lung cancer was 99. 3%. Conclusion Accuracy of deteting lung cancer by dog sniffing is over 99%, which can be used as an assistant tool for early screening of lung cancer.

Key words: dogs, smell discrimination, lung cancer, tumor screening